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Nanotechnology offers a range of possibilities to lead to biology. Listed here I'll current illustrations wherever nanofabrication – a chance to make confined buildings with Proportions at will – is made use of to look at the biophysics of one molecules and cells. I'll existing some illustrations from our lab:

1996, initially mesoscopic demand density waves gadgets; and initially electrical measurements on a single steel nanocluster involving nanoelectrodes

, Groningen researchers present the outcome of their initiatives to generate labs additional sustainable and supply guidelines for other labs. 

Non-equilibrium folding of unique DNA molecules recaptured as many as 1000 situations in the strong point out nanopore

This yielded a breakthrough. In only some months, we were capable of measure transportation by somebody single-walled carbon nanotube. According to lower-temperature experiments by an excellent PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft University of Technological innovation with an active exploration lab at AMOLF in Amsterdam), we showed that carbon nanotubes have been real quantum wires with quite very long (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.

The coiled-coil from the human Rad50 DNA maintenance protein is made up of particular segments of amplified versatility

We use nanofabricated microfluidic constructions to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks and this evaluate the elemental purpose of spatial confinement for the molecular and mobile stage. Our assignments incorporate the next:

Researching DNA loop extrusion by SMC proteins for ceesdekker.net chromosome architecture with solitary-molecule assays.

Understanding fundamental processes regulating the spatial and dynamic organisation of the DNA in live cells.

But carbon nanotubes have remained a investigation subject of significant curiosity to numerous. Certainly, the outlook on utilizing carbon nanotubes to build practical equipment, in spots for instance radio-frequency electronics, electronic electronics and flexible electronics, stays vibrant.

In 1993 he was appointed as Affiliate Professor at Delft College of Technologies. From the mid-nineteen nineties Dekker and his group realized success with the discovery on the Digital properties of carbon nanotubes, the initial solitary-molecule transistor and various nanoscience.

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2008, to start with observation of protein-coated DNA translocation via nanopores; resolved the origin of the electrophoretic force on DNA in nanopores; uncovered a substantial velocity improve of microtubules in electric powered fields; learned an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid

The biophysicist from Delft – who has been One of the more cited researchers in the Netherlands For some time – will take his responsibility to lead to the clarification and popularisation of his function for the border of physics and biology incredibly very seriously and often seems inside the media; Otherwise to speak about his do the job, then about the relationship involving science and his Christian faith.